[HTML][HTML] Fuzheng Kang-Ai decoction enhances the effect of Gefitinib-induced cell apoptosis in lung cancer through mitochondrial pathway
S Wang, Z Peng, W Li, S Long… - Cancer Cell …, 2020 - cancerci.biomedcentral.com
Our previous clinical study has shown that Chinese herbal medicine (CHM) Fuzheng Kang-
Ai (FZKA) decoction is effective in treating advanced lung cancer patients through
prolonging the drug resistance to Gefitinib (GFTN). Our basic study found that FZKA
decoction could enhance the inhibition effect of GFTN in lung cancer by inactivating PI3K/Akt
pathway. Moreover, our recent work showed that FZKA induced lung cancer cell apoptosis
via STAT3/Bcl-2/Caspase-3 pathway. Thus in this study, we aim to elucidate how FZKA …
Ai (FZKA) decoction is effective in treating advanced lung cancer patients through
prolonging the drug resistance to Gefitinib (GFTN). Our basic study found that FZKA
decoction could enhance the inhibition effect of GFTN in lung cancer by inactivating PI3K/Akt
pathway. Moreover, our recent work showed that FZKA induced lung cancer cell apoptosis
via STAT3/Bcl-2/Caspase-3 pathway. Thus in this study, we aim to elucidate how FZKA …
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